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Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.
Burbulla, Lena F; Song, Pingping; Mazzulli, Joseph R; Zampese, Enrico; Wong, Yvette C; Jeon, Sohee; Santos, David P; Blanz, Judith; Obermaier, Carolin D; Strojny, Chelsee; Savas, Jeffrey N; Kiskinis, Evangelos; Zhuang, Xiaoxi; Krüger, Rejko; Surmeier, D James; Krainc, Dimitri.
Afiliação
  • Burbulla LF; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Song P; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129, USA.
  • Mazzulli JR; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Zampese E; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Wong YC; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129, USA.
  • Jeon S; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Santos DP; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Blanz J; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Obermaier CD; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Strojny C; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Savas JN; Department for Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tübingen, DZNE, German Centre for Neurodegenerative Diseases, Tübingen, Germany.
  • Kiskinis E; Graduate School for Cellular and Molecular Neuroscience, University of Tübingen, Germany.
  • Zhuang X; Clinical and Experimental Neuroscience, Luxembourg Center for Systems Biomedicine, University of Luxembourg, Luxembourg.
  • Krüger R; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Surmeier DJ; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
  • Krainc D; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Science ; 357(6357): 1255-1261, 2017 09 22.
Article em En | MEDLINE | ID: mdl-28882997
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Dopamina / Estresse Oxidativo / Neurônios Dopaminérgicos / Lisossomos / Mitocôndrias Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Dopamina / Estresse Oxidativo / Neurônios Dopaminérgicos / Lisossomos / Mitocôndrias Idioma: En Ano de publicação: 2017 Tipo de documento: Article