Magneto-actuated cell apoptosis by biaxial pulsed magnetic field.
Sci Rep
; 7(1): 10919, 2017 09 07.
Article
em En
| MEDLINE
| ID: mdl-28883430
ABSTRACT
We report on a highly efficient magneto-actuated cancer cell apoptosis method using a biaxial pulsed magnetic field configuration, which maximizes the induced magnetic torque. The light transmissivity dynamics show that the biaxial magnetic field configuration can actuate the magnetic nanoparticles with higher responsiveness over a wide range of frequencies as compared to uniaxial field configurations. Its efficacy was demonstrated in in vitro cell destruction experiments with a greater reduction in cell viability. Magnetic nanoparticles with high aspect ratios were also found to form a triple vortex magnetization at remanence which increases its low field susceptibility. This translates to a larger magneto-mechanical actuated force at low fields and 12% higher efficacy in cell death as compared to low aspect ratio nanoparticles.
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Base de dados:
MEDLINE
Assunto principal:
Células HeLa
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Apoptose
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Nanopartículas Metálicas
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Campos Magnéticos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article