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Casein kinase 2 is a critical determinant of the balance of Th17 and Treg cell differentiation.
Jang, Sung Woong; Hwang, Soo Seok; Kim, Hyeong Su; Lee, Keoung Oh; Kim, Min Kyung; Lee, Wonyong; Kim, Kiwan; Lee, Gap Ryol.
Afiliação
  • Jang SW; Department of Life Science, Sogang University, Seoul, Korea.
  • Hwang SS; Department of Life Science, Sogang University, Seoul, Korea.
  • Kim HS; Department of Life Science, Sogang University, Seoul, Korea.
  • Lee KO; Department of Life Science, Sogang University, Seoul, Korea.
  • Kim MK; Department of Life Science, Sogang University, Seoul, Korea.
  • Lee W; Department of Life Science, Sogang University, Seoul, Korea.
  • Kim K; Department of Life Science, Sogang University, Seoul, Korea.
  • Lee GR; Department of Life Science, Sogang University, Seoul, Korea.
Exp Mol Med ; 49(9): e375, 2017 09 08.
Article em En | MEDLINE | ID: mdl-28883547
ABSTRACT
Th17 cells promote inflammatory reactions, whereas regulatory T (Treg) cells inhibit them. Thus, the Th17/Treg cell balance is critically important in inflammatory diseases. However, the molecular mechanisms underlying this balance are unclear. Here, we demonstrate that casein kinase 2 (CK2) is a critical determinant of the Th17/Treg cell balance. Both the inhibition of CK2 with a specific pharmacological inhibitor, CX-4945, and its small hairpin RNA (shRNA)-mediated knockdown suppressed Th17 cell differentiation but reciprocally induced Treg cell differentiation in vitro. Moreover, CX-4945 ameliorated the symptoms of experimental autoimmune encephalomyelitis and reduced Th17 cell infiltration into the central nervous system. Mechanistically, CX-4945 inhibited the IL-6/STAT3 and Akt/mTOR signaling pathways. Thus, CK2 has a crucial role in regulating the Th17/Treg balance.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Linfócitos T Reguladores / Caseína Quinase II / Células Th17 Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Linfócitos T Reguladores / Caseína Quinase II / Células Th17 Idioma: En Ano de publicação: 2017 Tipo de documento: Article