Mitochondrial DNA content: A new biomarker for sudden intrauterine unexplained death syndrome (SIUDS).
Mitochondrion
; 40: 13-15, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-28890118
ABSTRACT
In literature there are no data related to mitochondrial DNA (mtDNA) content in sudden intrauterine unexplained death syndrome (SIUDS). To test the hypothesis that a quantitative excess of mtDNA could play a role in the pathogenesis of SIUDS, mtDNA content was measured in cerebral cortex of 9 SIUDS and in 7 controls. The median (interquartile range) mtDNA in SIUDS and controls was 14,000 (8600-33,500), 3400 (0-8500) copies per nuclear DNA, respectively (p=0.007). If mitochondria are involved in SIUDS, then higher mitochondrial DNA content may be a biomarker of this syndrome.
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Base de dados:
MEDLINE
Assunto principal:
DNA Mitocondrial
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Biomarcadores
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Córtex Cerebral
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Variações do Número de Cópias de DNA
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Morte Fetal
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article