Your browser doesn't support javascript.
loading
Gene Modified T Cell Therapies for Hematological Malignancies.
Abramowski-Mock, Ulrike; Delhove, Juliette M; Qasim, Waseem.
Afiliação
  • Abramowski-Mock U; Molecular and Cellular Immunology Unit, University college London, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
  • Delhove JM; Molecular and Cellular Immunology Unit, University college London, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
  • Qasim W; Molecular and Cellular Immunology Unit, University college London, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address: w.qasim@ucl.ac.uk.
Hematol Oncol Clin North Am ; 31(5): 913-926, 2017 10.
Article em En | MEDLINE | ID: mdl-28895856
ABSTRACT
This article focuses on clinical applications of T cells transduced to express recombinant T cell receptor and chimeric antigen receptor constructs directed toward hematological malignancies, and considers newer strategies incorporating gene-editing technologies to address GvHD and host-mediated rejection. Recent data from clinical trials are reviewed, and an overview is provided of current and emerging manufacturing processes; consideration is also given to new developments in the pipeline.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Terapia Genética / Neoplasias Hematológicas / Terapia Baseada em Transplante de Células e Tecidos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Terapia Genética / Neoplasias Hematológicas / Terapia Baseada em Transplante de Células e Tecidos Idioma: En Ano de publicação: 2017 Tipo de documento: Article