[Diagnostic value of dynamic monitoring of C-reactive protein in drain drainage to predict early anastomotic leakage after colorectal cancer surgery].
Zhonghua Wei Chang Wai Ke Za Zhi
; 20(9): 1055-1059, 2017 Sep 25.
Article
em Zh
| MEDLINE
| ID: mdl-28901000
ABSTRACT
OBJECTIVE:
To evaluate the diagnostic value of dynamic monitoring of C-reactive protein (CRP) in drainage fluid in predicting early anastomotic leakage after colorectal surgery.METHODS:
This study enrolled 172 patients, who were diagnosed as colorectal cancer before operation and underwent radical surgery, without residual tumor tissues by postoperative pathology and perioperative infection, at the Tianjin Medical University Cancer Hospital between July 2015 and January 2016. The C-reactive(CRP) protein level in drainage fluid was continuously monitored from postoperative days (POD) 1 to 5. CRP level was compared between anastomotic leakage (AL) group and non-anastomotic leakage (NAL) group. Receiver operating characteristics (ROC) curve was used to estimate the value of monitoring CRP in drainage fluid to predict anastomotic leakage after colorectal surgery.RESULTS:
Among 172 patients, 101 cases were male and 71 cases were female, with age of (59.9±10.3) years. Anastomotic leakage occurred after colorectal surgery in 24 cases(14.0%, AL group ) and other 148 cases were defined as NAL group. Other than body mass index (BMI), differences in baseline data were not statistically significant between two groups. The CRP lever in AL group and NAL group showed rising trend from POD1 to POD4 [Day 1 (6.7±8.4) g/L vs. (8.0±10.6) g/L; Day 2 (24.8±14.6) g/L vs. (28.3±21.1) g/L, Day 3 (54.8±26.5) g/L vs. (53.8±27.6)g/L, Day 4 (62.0±32.2) g/L vs. (58.4±30.7) g/L], while the differences were not significant (all P>0.05). At POD 5, the CRP lever of AL group increased continuously, while that of NAL group decreased with significant difference [(65.3±38.9) g/L vs. (44.7±39.5) g/L, t=-2.85, P=0.005]. Further stratification analysis on AL group revealed CRP level in early AL (AL occurrenceCONCLUSION:
Continuous increase of CRP level in abdominal drainage fluid from POD 1 to POD 5 indicates the occurrence of AL after colorectal cancer operation, especially the detection of CRP level at POD 5 is important.
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Base de dados:
MEDLINE
Assunto principal:
Líquido Ascítico
/
Proteína C-Reativa
/
Neoplasias Colorretais
/
Colectomia
/
Fístula Anastomótica
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article