Cardiac side effects of bruton tyrosine kinase (BTK) inhibitors.
Leuk Lymphoma
; 59(7): 1554-1564, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-28901789
ABSTRACT
The development of bruton tyrosine kinase inhibitors (BTKi) has been a significant advancement in the treatment of chronic lymphocytic leukemia and related B-cell malignancies. As experience in using ibrutinib increased, the first drug to be licensed in its class, atrial fibrillation (AF) emerged as an important side effect. The intersection between BTKi therapy for B-cell malignancies and AF represents a complex area of management with scant evidence for guidance. Consideration needs to be taken regarding the interplay of increased bleeding risk versus thromboembolic complications of AF, drug interactions between ibrutinib and anticoagulants and antiarrhythmic agents, and the potential for other, as yet seldom reported cardiac side effects. This review describes the current knowledge regarding BTKi and potential pathophysiologic mechanisms of AF and discusses the management of BTKi-associated AF. Finally, a review of the second generation BTKi is provided and gaps in knowledge in this evolving field are highlighted.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteínas Quinases
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Cardiotoxicidade
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Tirosina Quinase da Agamaglobulinemia
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Antineoplásicos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article