Madurahydroxylactone, an Inhibitor of Staphylococcus aureus FtsZ from Nonomuraea sp. AN100570.
J Microbiol Biotechnol
; 27(11): 1994-1998, 2017 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-28910864
ABSTRACT
FtsZ, a bacterial cell-division protein, is an attractive antibacterial target. In the screening for an inhibitor of Staphylococcus aureus FtsZ, madurahydroxylactone (1) and its related derivatives 2-5 were isolated from Nonomuraea sp. AN100570. Compound 1 inhibited S. aureus FtsZ with an IC50 of 53.4 µM and showed potent antibacterial activity against S. aureus and MRSA with an MIC of 1 µg/ml, whereas 2-5 were weak or inactive. Importantly, 1 induced cell elongation in the cell division phenotype assay, whereas 2-5 did not. It indicates that 1 exhibits its potent antibacterial activity via inhibition of FtsZ, and the hydroxyl group and hydroxylactone ring of 1 are critical for the activity. Thus, madurahydroxylactone is a new type of inhibitor of FtsZ.
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Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
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Proteínas de Bactérias
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Actinobacteria
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Proteínas do Citoesqueleto
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Lactonas
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Antibacterianos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article