A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin To Promote Killing of Breast Cancer Cells.
J Med Chem
; 60(20): 8661-8666, 2017 10 26.
Article
em En
| MEDLINE
| ID: mdl-28921987
ABSTRACT
Cancer cell mitochondria are promising anticancer drug targets because they control cell death and are structurally and functionally different from normal cell mitochondria. We synthesized arylurea fatty acids and found that the analogue 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid (13b) decreased proliferation and activated apoptosis in MDA-MB-231 breast cancer cells in vitro and in vivo. In mechanistic studies 13b emerged as the prototype of a novel class of mitochondrion-targeted agents that deplete cardiolipin and promote cancer cell death.
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1
Base de dados:
MEDLINE
Assunto principal:
Ureia
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Neoplasias da Mama
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Ácidos Graxos
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Mitocôndrias
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article