Antifibrotic effects of pentoxifylline improve the efficacy of gemcitabine in human pancreatic tumor xenografts.

Kim, Jung Ho; Shin, Byung Cheol; Park, Won Sang; Lee, Jaehwi; Kuh, Hyo-Jeong

Kim, Jung Ho; Shin, Byung Cheol; Park, Won Sang; Lee, Jaehwi; Kuh, Hyo-Jeong.

Afiliação

Kim JH; Department of Biomedicine & Health Science, The Catholic University of Korea, Seoul, Korea.
Shin BC; Bio/Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Korea.
Park WS; Department of Pathology, The Catholic University of Korea, Seoul, Korea.
Lee J; College of Pharmacy, Chung-Ang University, Seoul, Korea.
Kuh HJ; Department of Biomedicine & Health Science, The Catholic University of Korea, Seoul, Korea.

Cancer Sci ; 108(12): 2470-2477, 2017 Dec.

Article em En | MEDLINE | ID: mdl-28940685

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Desoxicitidina/análogos & derivados; Neoplasias Pancreáticas/patologia; Pentoxifilina/farmacologia; Animais; Desoxicitidina/farmacologia; Sinergismo Farmacológico; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Inibidores de Fosfodiesterase/farmacologia; Distribuição Tecidual; Ensaios Antitumorais Modelo de Xenoenxerto; Gencitabina

Palavras-chave

Connective tissue growth factor; desmoplasia; gemcitabine; pancreatic ductal adenocarcinoma; pentoxifylline

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Pentoxifilina / Protocolos de Quimioterapia Combinada Antineoplásica / Desoxicitidina Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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