Effect of GRP119 Receptor Agonist, Compound MBX-2982, on Activity of Human Glucokinase.

Spasov, A A; Kosolapov, V A; Babkov, D A; Maika, O Yu

Spasov, A A; Kosolapov, V A; Babkov, D A; Maika, O Yu.

Afiliação

Spasov AA; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia. aspasov@mail.ru.
Kosolapov VA; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
Babkov DA; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.
Maika OY; Volgograd State Medical University, Ministry of Health of the Russian Federation, Volgograd, Russia.

Bull Exp Biol Med ; 163(5): 695-698, 2017 Sep.

Article em En | MEDLINE | ID: mdl-28944428

ABSTRACT

ABSTRACT

Validation of the method for studies of glucokinase activators by the spectrophotometric method in an in vitro test system is carried out. The advantage of NAD coenzyme vs. thio-NAD is proven. Manifest activation of glucokinase by MBX-2982 compound (GPR119 agonist) in a wide range of concentrations is demonstrated experimentally.

Assuntos

Glucoquinase/metabolismo; Tetrazóis/farmacologia; Tiazóis/farmacologia; Ativação Enzimática/efeitos dos fármacos; Humanos; Estrutura Molecular; Receptores Acoplados a Proteínas G/metabolismo; Tetrazóis/química; Tiazóis/química

Palavras-chave

glucokinase; glucokinase activators; hexokinase; type 2 diabetes mellitus

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetrazóis / Tiazóis / Glucoquinase Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetrazóis / Tiazóis / Glucoquinase Idioma: En Ano de publicação: 2017 Tipo de documento: Article