Immunoreactivities of calbindinD28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging.
Mol Med Rep
; 16(5): 7191-7198, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28944879
CalbindinD28k (CB), calretinin (CR) and parvalbumin (PV), which regulate cytosolic free Ca2+ concentrations in neurons, are chemically expressed in γaminobutyric acid (GABA)ergic neurons that regulate the degree of glutamatergic excitation and output of projection neurons. The present study investigated ageassociated differences in CB, CR and PV immunoreactivities in the somatosensory cortex in three species (mice, rats and gerbils) of young (1 month), adult (6 months) and aged (24 months) rodents, using immunohistochemistry and western blotting. Abundant CBimmunoreactive neurons were distributed in layers II and III, and ageassociated alterations in their number were different according to the species. CRimmunoreactive neurons were not abundant in all layers; however, the number of CRimmunoreactive neurons was the highest in all adult species. Many PVimmunoreactive neurons were identified in all layers, particularly in layers II and III, and they increased in all layers with age in all species. The present study demonstrated that the distribution pattern of CB, CR and PVcontaining neurons in the somatosensory cortex were apparently altered in number with normal aging, and that CB and CR exhibited a tendency to decrease in aged rodents, whereas PV tended to increase with age. These results indicate that CB, CR and PV are markedly altered in the somatosensory cortex, and this change may be associated with normal aging. These findings may aid the elucidation of the mechanisms of aging and geriatric disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Parvalbuminas
/
Córtex Somatossensorial
/
Envelhecimento
/
Calbindina 1
/
Calbindina 2
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article