Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP2 and MMP9.
Mol Med Rep
; 16(5): 7513-7519, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28944890
ABSTRACT
Paeonol (Pae) is an herbal extract that has attracted extensive attention for its anticancer effects demonstrated by a number of studies, which have predominantly demonstrated inhibition of cell proliferation and induction of apoptosis. The influence of Pae on cancer cell metastasis has been less widely reported. The present study aimed to investigate the underreported effects of Pae on the growth, invasion and migration of poorly differentiated BGC823 gastric cancer cells with strong invasive and metastatic abilities. The antiproliferative and proapoptotic effects of Pae on BGC823 cells were verified by Cell Counting kit8 and Annexin Vfluorescein isothiocyanate/propidium iodide assays. Cell scratchwound healing and Transwell methods were applied, and it was demonstrated that Pae could exert inhibitory activities on the invasion and migration of BGC823 cells. Furthermore, it was indicated by western blot analysis that Pae could downregulate the protein expression levels of matrix metalloproteinase (MMP)2 and 9 in a concentrationdependent manner, which may support a novel potential mechanism accounting for its anticancer effects on gastric cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetofenonas
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Regulação para Baixo
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Metaloproteinase 2 da Matriz
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Metaloproteinase 9 da Matriz
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Proliferação de Células
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article