Silver-Mediated Direct C-H Cyanation of Terminal Alkynes with N-Isocyanoiminotriphenylphosphorane.
Org Lett
; 19(20): 5613-5616, 2017 10 20.
Article
em En
| MEDLINE
| ID: mdl-28961010
ABSTRACT
A direct cyanation of terminal alkynes for the synthesis of propionitrile derivatives, with the aid of silver salt using water additive, has been achieved. The cyano source used is N-isocyanoiminotriphenylphosphorane, which is nontoxic, safe, and easy to handle. This protocol is characterized by its operational simplicity, high efficiency with excellent yields, broad substrate scope, and greater functional group tolerance.
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MEDLINE
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En
Ano de publicação:
2017
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Article