Contemporary Pharmacotherapy for Allergic Rhinitis and Chronic Rhinosinusitis.
Otolaryngol Clin North Am
; 50(6): 1135-1151, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-28964532
ABSTRACT
Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are chronic conditions causing nasal inflammation. CRS is increasingly recognized as a chronic inflammatory process rather than a chronic infection. Although the primary initiating factors in CRS remain unclear, AR is driven by IgE-mediated hypersensitivity to environmental allergens. Understanding the underlying inflammatory pathways and disease endotypes are driving innovation toward novel pharmacotherapies targeting critical mediators implicated in CRS and AR, including IL-4, IL-13, IL-5, IgE, and epithelial initiators IL-33 and TSLP. Extensive investigations are needed to determine the role, timing, predictive prognostic factors and long-term safety and efficacy of these agents.
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Base de dados:
MEDLINE
Assunto principal:
Sinusite
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Terapia Biológica
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Alérgenos
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Antialérgicos
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Rinite Alérgica
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article