Liver cyst gene knockout in cholangiocytes inhibits cilium formation and Wnt signaling.

Wills, Edgar S; Te Morsche, René H M; van Reeuwijk, Jeroen; Horn, Nicola; Geomini, Iris; van de Laarschot, Liyanne F M; Mans, Dorus A; Ueffing, Marius; Boldt, Karsten; Drenth, Joost P H; Roepman, Ronald

Wills, Edgar S; Te Morsche, René H M; van Reeuwijk, Jeroen; Horn, Nicola; Geomini, Iris; van de Laarschot, Liyanne F M; Mans, Dorus A; Ueffing, Marius; Boldt, Karsten; Drenth, Joost P H; Roepman, Ronald.

Afiliação

Wills ES; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Te Morsche RHM; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
van Reeuwijk J; Department of Human Genetics and Radboud Insitute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Horn N; Division of Experimental Ophthalmology and Medical Bioanalytics, Center for Ophthalmology, Eberhard-Karls University Tübingen, 72076, Tübingen, Germany.
Geomini I; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
van de Laarschot LFM; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Mans DA; Department of Human Genetics and Radboud Insitute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Ueffing M; Division of Experimental Ophthalmology and Medical Bioanalytics, Center for Ophthalmology, Eberhard-Karls University Tübingen, 72076, Tübingen, Germany.
Boldt K; Division of Experimental Ophthalmology and Medical Bioanalytics, Center for Ophthalmology, Eberhard-Karls University Tübingen, 72076, Tübingen, Germany.
Drenth JPH; Department of Gastroenterology and Hepatology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Roepman R; Department of Human Genetics and Radboud Insitute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.

Hum Mol Genet ; 26(21): 4190-4202, 2017 11 01.

Article em En | MEDLINE | ID: mdl-28973524

Assuntos

Cílios/patologia; Cistos/metabolismo; Cistos/patologia; Glucosidases/metabolismo; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Hepatopatias/metabolismo; Hepatopatias/patologia; Proteínas de Membrana/metabolismo; Proteínas de Ligação ao Cálcio; Cílios/genética; Cílios/metabolismo; Cistos/genética; Retículo Endoplasmático/patologia; Técnicas de Inativação de Genes; Glucosidases/genética; Células HEK293; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/genética; Fígado/metabolismo; Fígado/patologia; Hepatopatias/genética; Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/genética; Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/metabolismo; Proteínas de Membrana/genética; Chaperonas Moleculares; Proteínas de Ligação a RNA; Via de Sinalização Wnt; Proteína Wnt1/genética; Proteína Wnt1/metabolismo; alfa-Glucosidases/metabolismo; beta Catenina/genética; beta Catenina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cílios / Cistos / Peptídeos e Proteínas de Sinalização Intracelular / Glucosidases / Hepatopatias / Proteínas de Membrana Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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