The µ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment.
Pharmacogenomics
; 18(15): 1387-1391, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-28976288
ABSTRACT
AIM:
This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with µ-opioid receptor agonist.METHODS:
Genotypes of 71 SNPs, in nine genes, were analyzed for association with long-term abstinence in former heroin-dependents of European/Middle Eastern ancestry, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 922).RESULTS:
The functional OPRM1 nonsynonymous SNP rs1799971 (118A>G) showed significant association with long-term abstinence (Ppermutation = 0.03, dominant model, OR 2.2; 95% CI 1.5-3.3).CONCLUSION:
Since the stress axis is regulated in part by ß-endorphin, this functional OPRM1 SNP may blunt the endogenous stress response and contribute to reduced vulnerability for relapse.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Receptores Opioides mu
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Polimorfismo de Nucleotídeo Único
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Heroína
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Dependência de Heroína
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article