Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis.

Jensen, Brian C; Parry, Traci L; Huang, Wei; Beak, Ju Youn; Ilaiwy, Amro; Bain, James R; Newgard, Christopher B; Muehlbauer, Michael J; Patterson, Cam; Johnson, Gary L; Willis, Monte S

Jensen, Brian C; Parry, Traci L; Huang, Wei; Beak, Ju Youn; Ilaiwy, Amro; Bain, James R; Newgard, Christopher B; Muehlbauer, Michael J; Patterson, Cam; Johnson, Gary L; Willis, Monte S.

Afiliação

Jensen BC; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
Parry TL; Department of Internal Medicine, Division of Cardiology University of North Carolina, Chapel Hill, NC, USA.
Huang W; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.
Beak JY; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
Ilaiwy A; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA.
Bain JR; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
Newgard CB; McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
Muehlbauer MJ; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Patterson C; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Johnson GL; Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA.
Willis MS; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Br J Pharmacol ; 174(24): 4797-4811, 2017 Dec.

Article em En | MEDLINE | ID: mdl-28977680

Assuntos

Coração/efeitos dos fármacos; Fígado/efeitos dos fármacos; Metabolômica; Músculo Esquelético/efeitos dos fármacos; Niacinamida/análogos & derivados; Compostos de Fenilureia/farmacologia; Plasma/efeitos dos fármacos; Inibidores de Proteínas Quinases/farmacologia; Animais; Fígado/metabolismo; Camundongos; Camundongos Endogâmicos; Músculo Esquelético/metabolismo; Niacinamida/química; Niacinamida/farmacologia; Compostos de Fenilureia/química; Plasma/metabolismo; Inibidores de Proteínas Quinases/química; Sorafenibe; Distribuição Tecidual

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Fenilureia / Plasma / Niacinamida / Músculo Esquelético / Inibidores de Proteínas Quinases / Metabolômica / Coração / Fígado Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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