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PGE1 and E3 show lower efficacies than E2 to ß-catenin-mediated activity as biased ligands of EP4 prostanoid receptors.
Araki, Yumi; Suganami, Akiko; Endo, Suzu; Masuda, Yuta; Fukushima, Keijo; Regan, John W; Murayama, Toshihiko; Tamura, Yutaka; Fujino, Hiromichi.
Afiliação
  • Araki Y; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan.
  • Suganami A; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan.
  • Endo S; Department of Bioinformatics, Graduate School of Medicine, Chiba University, Japan.
  • Masuda Y; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan.
  • Fukushima K; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan.
  • Regan JW; Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Graduate School of Biomedical Sciences, Tokushima University, Japan.
  • Murayama T; Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, AZ, USA.
  • Tamura Y; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan.
  • Fujino H; Department of Bioinformatics, Graduate School of Medicine, Chiba University, Japan.
FEBS Lett ; 591(22): 3771-3780, 2017 11.
Article em En | MEDLINE | ID: mdl-28986997
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alprostadil / Dinoprostona / Beta Catenina / Receptores de Prostaglandina E Subtipo EP4 Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alprostadil / Dinoprostona / Beta Catenina / Receptores de Prostaglandina E Subtipo EP4 Idioma: En Ano de publicação: 2017 Tipo de documento: Article