Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease.
Pharmacol Ther
; 183: 34-49, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-28987319
ABSTRACT
Cellular senescence, the irreversible loss of replicative capacity in somatic cells, plays a causal role in the development of age-related pathology and in a number of age-related chronic inflammatory diseases. The ageing lung is marked by an increasing number of senescent cells, and evidence is mounting that senescence may directly contribute to a number of age-related respiratory diseases, including chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Telomere dysfunction and alterations in mitochondrial homeostasis frequently occur in cellular senescence and are important to the development of the often detrimental senescence-associated secretory phenotype (SASP). The roles of telomeres, the mitochondria and cellular senescence in lung ageing and disease are discussed. Therapeutic interventions targeting cellular senescence are considered for delaying or potentially reversing age-related respiratory disease.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Telômero
/
Senescência Celular
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Pneumopatias
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Mitocôndrias
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article