Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice.

Pires, Karla Maria; Buffolo, Marcio; Schaaf, Christin; David Symons, J; Cox, James; Abel, E Dale; Selzman, Craig H; Boudina, Sihem

Pires, Karla Maria; Buffolo, Marcio; Schaaf, Christin; David Symons, J; Cox, James; Abel, E Dale; Selzman, Craig H; Boudina, Sihem.

Afiliação

Pires KM; Department of Nutrition and Integrative Physiology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Buffolo M; Department of Nutrition and Integrative Physiology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Schaaf C; Division of Cardiothoracic Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
David Symons J; Department of Nutrition and Integrative Physiology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Cox J; Department of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Abel ED; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA.
Selzman CH; Division of Cardiothoracic Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA.
Boudina S; Department of Nutrition and Integrative Physiology, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address: sihem.boudina@hmbg.utah.edu.

J Mol Cell Cardiol ; 113: 39-50, 2017 12.

Article em En | MEDLINE | ID: mdl-28987875

Assuntos

Autofagia/fisiologia; Cardiomegalia/metabolismo; Diabetes Mellitus Experimental/metabolismo; Hiperinsulinismo/metabolismo; Obesidade/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Receptor IGF Tipo 1/metabolismo; Animais; Diabetes Mellitus Tipo 2/metabolismo; Coração/fisiologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Obesos; Transdução de Sinais/fisiologia; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

Akt; Autophagy; Cardiac function; IGF-1 receptors; Insulin receptors; mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Receptor IGF Tipo 1 / Cardiomegalia / Diabetes Mellitus Experimental / Proteínas Proto-Oncogênicas c-akt / Hiperinsulinismo / Obesidade Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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