Dorsal Raphe Serotonergic Neurons Control Intertemporal Choice under Trade-off.
Curr Biol
; 27(20): 3111-3119.e3, 2017 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-28988863
ABSTRACT
Appropriate choice about delayed reward is fundamental to the survival of animals. Although animals tend to prefer immediate reward, delaying gratification is often advantageous. The dorsal raphe (DR) serotonergic neurons have long been implicated in the processing of delayed reward, but it has been unclear whether or when their activity causally directs choice. Here, we transiently augmented or reduced the activity of DR serotonergic neurons, while mice decided between differently delayed rewards as they performed a novel odor-guided intertemporal choice task. We found that these manipulations, precisely targeted at the decision point, were sufficient to bidirectionally influence impulsive choice. The manipulation specifically affected choices with more difficult trade-off. Similar effects were observed when we manipulated the serotonergic projections to the nucleus accumbens (NAc). We propose that DR serotonergic neurons preempt reward delays at the decision point and play a critical role in suppressing impulsive choice by regulating decision trade-off.
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Base de dados:
MEDLINE
Assunto principal:
Recompensa
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Comportamento de Escolha
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Neurônios Serotoninérgicos
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Núcleo Dorsal da Rafe
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Comportamento Impulsivo
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article