Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174.
Biochem Biophys Res Commun
; 494(1-2): 332-338, 2017 12 09.
Article
em En
| MEDLINE
| ID: mdl-29017923
ABSTRACT
Lysophosphatidylserine (LysoPS) has been shown to have lipid mediator-like actions to induce mast cell degranulation and suppress T lymphocyte proliferation. Recently, three G protein-coupled receptors (GPCRs), LPS1/GPR34, LPS2/P2Y10, and LPS3/GPR174, were found to react specifically with LysoPS, raising the possibility that LysoPS exerts its roles through these receptors. In this study, we show that LPS3 is expressed in various T cell subtypes and is involved in suppression of Interleukin-2 (IL-2) production in CD4 T cells. We found that LysoPS suppressed the IL-2 production from activated T cells at the mRNA and protein levels. In addition, LysoPS did not have such an effect on the splenocytes and CD4 T cells isolated from LPS3-deficient mice. In LPS3-deficient splenocytes and CD4 T cells, anti-CD3/anti-CD28-triggered IL-2 production is somewhat increased. Interestingly, LysoPS with various fatty acids was up-regulated upon T cell activation. The present study raised the possibility that LysoPS exerts its immunosuppressive roles by down-regulating IL-2 production through a LysoPS-LPS3 axis in T cells.
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MEDLINE
Assunto principal:
Lisofosfolipídeos
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Linfócitos T CD4-Positivos
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Interleucina-2
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Receptores Purinérgicos P2
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Receptores Acoplados a Proteínas G
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Receptores de Lisofosfolipídeos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article