[Expression of pituitary tumor-transforming gene 1 during the development of androgen-independent prostate cancer].
Zhonghua Nan Ke Xue
; 22(8): 686-691, 2016 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-29019223
ABSTRACT
OBJECTIVE:
To explore the expression of pituitary tumor transforming gene 1 (PTTG1) during the transformation of prostate cancer from androgen-dependent (ADPC) to androgen-independent (AIPC).METHODS:
We established an AIPC cell model LNCaP-AI by culturing the androgen-dependent LNCaP cell line in the hormone-deprived medium for over 3 months. The cell model was verified and the PTTG1 expression in the LNCaP cells was detected by Western blot and RT-PCR during hormone deprivation.RESULTS:
The AIPC cell model LNCaP-AI was successfully established. The PTTG1 expression was gradually increased in the LNCaP cells with the prolonged time of hormone deprivation and the expressions of matrix metalloproteinases MMP-2 and -9 were elevated at the same time.CONCLUSIONS:
The expression of PTTG1 is increased gradually in AIPC, which may be a target of gene therapy for advanced prostate cancer.Palavras-chave
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Regulação Neoplásica da Expressão Gênica
/
Securina
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article