Multiple Evanescent White Dot Syndrome Following Acute Epstein-Barr Virus Infection.
Ocul Immunol Inflamm
; 27(2): 244-250, 2019.
Article
em En
| MEDLINE
| ID: mdl-29020489
ABSTRACT
PURPOSE:
To investigate the association between multiple evanescent white dot syndrome (MEWDS) and Epstein-Barr (EB) virus infection.METHODS:
A prospective, consecutive case series study was performed in patients with the characteristic findings of MEWDS. Patients received EB viral-specific antibody serologic tests.RESULTS:
Five cases of MEWDS who had prodromal flu-like symptoms were enrolled, comprising 2 women and 3 men with a mean age of 34. Mean diopter of myopia was -7.5. During acute onset of MEWDS, EB virus infection was confirmed by positive EB virus serology test. One showed positive EB viral capsid antigen (EB-VCA) IgM, and the other four showed highly elevated titer of EB-VCA IgG more than 1160. Two months later, paired serum virus serology data showed negative EB-VCA IgM, or prior EB-VCA IgG titer decreased four-fold in the recovery stage.CONCLUSION:
MEWDS may be associated with acute systemic EB virus infection. Ocular symptoms might develop due to this infection or represent virus-induced autoimmune inflammatory retinitis.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retina
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Herpesvirus Humano 4
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Infecções por Vírus Epstein-Barr
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Síndrome dos Pontos Brancos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article