Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.

Hassell, Bryan A; Goyal, Girija; Lee, Esak; Sontheimer-Phelps, Alexandra; Levy, Oren; Chen, Christopher S; Ingber, Donald E

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro.

Hassell, Bryan A; Goyal, Girija; Lee, Esak; Sontheimer-Phelps, Alexandra; Levy, Oren; Chen, Christopher S; Ingber, Donald E.

Afiliação

Hassell BA; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA.
Goyal G; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Lee E; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA.
Sontheimer-Phelps A; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Department of Biology, University of Freiburg, Freiburg, Germany.
Levy O; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Chen CS; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Department of Biomedical Engineering and the Biological Design Center, Boston University, Boston, MA 02215, USA.
Ingber DE; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA; Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA; Vascular Biology Program and Department of Surgery, Boston Children's Hospital and Harvard Medical School,

Cell Rep ; 21(2): 508-516, 2017 Oct 10.

Article em En | MEDLINE | ID: mdl-29020635

Assuntos

Dispositivos Lab-On-A-Chip; Neoplasias Pulmonares/patologia; Mucosa Respiratória/citologia; Antineoplásicos/farmacologia; Células Cultivadas; Receptores ErbB/metabolismo; Humanos; Neoplasias Pulmonares/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-met/metabolismo; Mucosa Respiratória/efeitos dos fármacos; Mucosa Respiratória/metabolismo; Transdução de Sinais

Palavras-chave

EGFR inhibitor; chemotherapy; invasion; lung cancer; mechanical; mechanobiology; microfluidic; organ-on-chip; persister cell; tyrosine kinase inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mucosa Respiratória / Dispositivos Lab-On-A-Chip / Neoplasias Pulmonares Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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