Helicobacter pylori Vacuolating Toxin and Gastric Cancer.
Toxins (Basel)
; 9(10)2017 10 12.
Article
em En
| MEDLINE
| ID: mdl-29023421
ABSTRACT
Helicobacter pylori VacA is a channel-forming toxin unrelated to other known bacterial toxins. Most H. pylori strains contain a vacA gene, but there is marked variation among strains in VacA toxin activity. This variation is attributable to strain-specific variations in VacA amino acid sequences, as well as variations in the levels of VacA transcription and secretion. In this review, we discuss epidemiologic studies showing an association between specific vacA allelic types and gastric cancer, as well as studies that have used animal models to investigate VacA activities relevant to gastric cancer. We also discuss the mechanisms by which VacA-induced cellular alterations may contribute to the pathogenesis of gastric cancer.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Proteínas de Bactérias
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Helicobacter pylori
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article