Identification of N-linked glycosylation sites in the spike protein and their functional impact on the replication and infectivity of coronavirus infectious bronchitis virus in cell culture.

Zheng, Jie; Yamada, Yoshiyuki; Fung, To Sing; Huang, Mei; Chia, Raymond; Liu, Ding Xiang

Zheng, Jie; Yamada, Yoshiyuki; Fung, To Sing; Huang, Mei; Chia, Raymond; Liu, Ding Xiang.

Afiliação

Zheng J; South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong, People's Republic of China; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapo
Yamada Y; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673.
Fung TS; South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong, People's Republic of China.
Huang M; School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 63755.
Chia R; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673.
Liu DX; South China Agricultural University, Guangdong Province Key Laboratory Microbial Signals & Disease Co, and Integrative Microbiology Research Centre, Guangzhou 510642, Guangdong, People's Republic of China. Electronic address: dxliu0001@163.com.

Virology ; 513: 65-74, 2018 01 01.

Article em En | MEDLINE | ID: mdl-29035787

Assuntos

Vírus da Bronquite Infecciosa/fisiologia; Glicoproteína da Espícula de Coronavírus/metabolismo; Internalização do Vírus; Replicação Viral; Substituição de Aminoácidos; Animais; Chlorocebus aethiops; Biologia Computacional; Análise Mutacional de DNA; Glicosilação; Vírus da Bronquite Infecciosa/genética; Proteômica; Glicoproteína da Espícula de Coronavírus/genética; Células Vero; Cultura de Vírus

Palavras-chave

Cell-cell fusion; Clone; Coronavirus; Infectious bronchitis virus; Infectious cDNA; N-linked glycosylation; Spike protein; Virus infectivity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Vírus da Bronquite Infecciosa / Internalização do Vírus / Glicoproteína da Espícula de Coronavírus Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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