Boric Acid Induced Transient Cross-Links in Lactose-Modified Chitosan (Chitlac).
Biomacromolecules
; 18(12): 4206-4213, 2017 Dec 11.
Article
em En
| MEDLINE
| ID: mdl-29039653
ABSTRACT
The present paper explores the effect of boric acid on Chitlac, a lactose-modified chitosan which had previously shown interesting biological and physical-chemical features. The herewith-reported experimental evidences demonstrated that boric acid binds to Chitlac, producing conformational and association effects on the chitosan derivative. The thermodynamics of boric acid binding to Chitlac was explored by means of 11B NMR, circular dichroism (CD), and UV-vis spectroscopy, while macromolecular effects were investigated by means of viscometry and dynamic light scattering (DLS). The experimental results revealed a chain-chain association when limited amounts of boric acid were added to Chitlac. However, upon exceeding a critical boric acid limit dependent on the polysaccharide concentration, the soluble aggregates disentangle. The rheological behavior of Chitlac upon treatment with boric acid was explored showing a dilatant behavior in conditions of steady flow. An uncommonly high dependence in the scaling law between the zero-shear viscosity and the concentration of Chitlac was found, i.e., η0 â CCTL5.8, pointing to interesting potential implications of the present system in biomaterials development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Bóricos
/
Quitosana
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Lactose
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article