Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia.

Peng, Luyun; Tang, Yuanting; Zhang, Yingchi; Guo, Siqi; Peng, Leiwen; Ye, Lei; Wang, Yuefang; Jiang, Yongmei

Peng, Luyun; Tang, Yuanting; Zhang, Yingchi; Guo, Siqi; Peng, Leiwen; Ye, Lei; Wang, Yuefang; Jiang, Yongmei.

Afiliação

Peng L; a Department of Laboratory Medicine , West China Second University Hospital, Sichuan University , Chengdu , China.
Tang Y; b Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education , Chengdu , China.
Zhang Y; a Department of Laboratory Medicine , West China Second University Hospital, Sichuan University , Chengdu , China.
Guo S; b Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education , Chengdu , China.
Peng L; c State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital , Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , China.
Ye L; a Department of Laboratory Medicine , West China Second University Hospital, Sichuan University , Chengdu , China.
Wang Y; b Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education , Chengdu , China.
Jiang Y; a Department of Laboratory Medicine , West China Second University Hospital, Sichuan University , Chengdu , China.

Leuk Lymphoma ; 59(10): 2423-2430, 2018 10.

Article em En | MEDLINE | ID: mdl-29043883

Assuntos

Adenosina Trifosfatases/metabolismo; Proteínas Cromossômicas não Histona/metabolismo; Leucemia Experimental/patologia; Leucemia Mieloide Aguda/patologia; Células-Tronco Neoplásicas/patologia; Adenosina Trifosfatases/genética; Adolescente; Animais; Medula Óssea/patologia; Transplante de Medula Óssea; Proteínas Cromossômicas não Histona/genética; Progressão da Doença; Técnicas de Silenciamento de Genes; Células HEK293; Humanos; Leucemia Experimental/genética; Leucemia Mieloide Aguda/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Proteína de Leucina Linfoide-Mieloide/genética; Proteínas de Fusão Oncogênica/genética; RNA Interferente Pequeno/metabolismo

Palavras-chave

AML; LSCs; MLL-AF9; SMC4; cell-cycle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Proteínas Cromossômicas não Histona / Leucemia Mieloide Aguda / Leucemia Experimental / Adenosina Trifosfatases Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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