Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength.
Med Sci Sports Exerc
; 49(11): 2240-2249, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-29045325
ABSTRACT
PURPOSE:
Calorie restriction (CR) improves health span and delays age-related diseases in many species. The multicenter Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) study was the first randomized controlled trial of CR in nonobese humans. The aim of this investigation was to determine the effects of CR on VËO2max and muscle strength in the CALERIE trial.METHODS:
Healthy, normal-weight, and mildly overweight women and men (n = 218, mean ± SE age = 37.9 ± 0.5 yr) were randomized to 25% CR or an ad libitum (AL) control condition in a 21 allocation (143 CR, 75 AL). VËO2max was determined with an incremental treadmill test; the strength of the knee flexors and extensors was assessed by dynamometry at baseline, 1 yr, and 2 yr.RESULTS:
The CR group achieved an average 11.9% ± 0.7% CR during the 2-yr intervention. Body weight decreased in CR (-7.7 ± 0.4 kg), but not AL (+0.2 ± 0.5 kg). Absolute VËO2max (L·min) decreased at 1 and 2 yr with CR, whereas VËO2max expressed relative to body mass increased at both time points (1 yr +2.2 ± 0.4; 2 yr +1.9 ± 0.5 mL·kg·min) and relative to AL. The CR group increased their treadmill test time and workload at 1 and 2 yr. Strength results in CR were similar, with decreases in absolute flexor and extensor strength, but increases when expressed relative to body mass. No changes were observed for VËO2max expressed relative to lean body mass or leg lean mass.CONCLUSIONS:
Two years of modest CR without a structured exercise component did not appear to compromise aerobic capacity in healthy nonobese adults. The clinical implications of the observed changes in VËO2max and muscle strength will be important to explore in future studies.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
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Restrição Calórica
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Força Muscular
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article