(-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways.

Satonaka, Hana; Ishida, Kumiki; Takai, Miho; Koide, Ryoji; Shigemasa, Ryota; Ueyama, Jun; Ishikawa, Tetsuya; Hayashi, Kazuhiko; Goto, Hidemi; Wakusawa, Shinya

Satonaka, Hana; Ishida, Kumiki; Takai, Miho; Koide, Ryoji; Shigemasa, Ryota; Ueyama, Jun; Ishikawa, Tetsuya; Hayashi, Kazuhiko; Goto, Hidemi; Wakusawa, Shinya.

Afiliação

Satonaka H; Division of Medical Laboratory Sciences, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ishida K; Division of Medical Laboratory Sciences, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takai M; Division of Medical Laboratory Sciences, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Koide R; Division of Medical Laboratory Sciences, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shigemasa R; Division of Medical Laboratory Sciences, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ueyama J; Division of Medical Laboratory Sciences, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ishikawa T; Division of Medical Laboratory Sciences, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hayashi K; Division of Gastroenterology, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Goto H; Division of Gastroenterology, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Wakusawa S; Division of Medical Laboratory Sciences, Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan wakusawa@met.nagoya-u.ac.jp.

Anticancer Res ; 37(11): 6071-6077, 2017 11.

Article em En | MEDLINE | ID: mdl-29061787

Assuntos

Carcinoma Hepatocelular/metabolismo; Catequina/análogos & derivados; Doxorrubicina/farmacologia; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Inibidores de Fosfoinositídeo-3 Quinase; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Subfamília B de Transportador de Cassetes de Ligação de ATP/antagonistas & inibidores; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética; Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo; Antibióticos Antineoplásicos/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Carcinoma Hepatocelular/patologia; Catequina/farmacologia; Humanos; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Fármacos Neuroprotetores/farmacologia; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Fosforilação/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Rodamina 123/metabolismo; Transdução de Sinais; Células Tumorais Cultivadas

Palavras-chave

EGCG; MEK/ERK; P-glycoprotein; PI3K/Akt; doxorubicin

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Base de dados: MEDLINE Assunto principal: Doxorrubicina / Catequina / Regulação Neoplásica da Expressão Gênica / Carcinoma Hepatocelular / Sistema de Sinalização das MAP Quinases / Proteínas Proto-Oncogênicas c-akt / Inibidores de Fosfoinositídeo-3 Quinase Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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