Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis.
Exp Dermatol
; 27(1): 101-103, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29078003
ABSTRACT
Healing of leishmaniasis-a parasitic skin disease-is associated with high levels of secreted interferon (IFN)γ and IL-12 in resistant C57BL/6 mice and humans. Susceptible BALB/c mice predominantly react with a Th17/Th2/Treg-related immune response and finally succumb to infection. Previously, we showed that BALB/c IL-17A-/- mice are protected against Leishmania (L.) major infections, indicating that IL-17A-predominantly produced by Th17 cells-plays an important role for disease outcome. We now investigated DC-derived cytokines and finally identified IL-23p19 as key cytokine responsible for induction of Leishmania-specific Th17 cells that play an important role for progressive disease in susceptible BALB/c mice.
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Base de dados:
MEDLINE
Assunto principal:
Leishmaniose Cutânea
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Subunidade p19 da Interleucina-23
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Células Th17
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article