Control of innate-like B cell location for compartmentalised IgM production.
Curr Opin Immunol
; 50: 9-13, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29078198
ABSTRACT
Natural IgM are crucial for early protection against infection and play an important homeostatic function by clearing dead cells. The production of IgM is ensured by a population of B cells with innate-like properties their response is rapidly activated by innate signals early during the onset of infection. The main reservoir of innate-like B cells (IBCs) are the serous cavities, but their maintenance and activation depends on their relocation to a variety of lymphoid tissues. Recent advances indicate that fat-associated lymphoid clusters (FALCs) and milky spots contribute to local IgM secretion and play a central role in the localisation and regulation of IBC function.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina M
/
Ativação Linfocitária
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Subpopulações de Linfócitos B
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Imunidade Inata
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Formação de Anticorpos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article