Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity.
Phytochemistry
; 145: 40-47, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29080411
ABSTRACT
Six previously undescribed diterpenoids, named euphorantins S-T and euphorneroids A-D, including ingol and ent-atisane types, along with eleven known diterpenoids, were isolated from Euphorbia neriifolia. Their structures were elucidated on the basis of extensive NMR analysis and high resolution mass spectrometry. Euphorneroid D and ent-3-oxoatisan-16α,17-acetonide exhibited moderate anti-HIV-1 activities, with EC50 values of 34 µM (SI = 2.3) and 24 µM (SI = 1.9), respectively.
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Base de dados:
MEDLINE
Assunto principal:
HIV-1
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Caules de Planta
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Fármacos Anti-HIV
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Euphorbia
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Casca de Planta
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Diterpenos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article