A comparison of estimates of doses to radiotherapy patients obtained with the dicentric chromosome analysis and the γ-H2AX assay: Relevance to radiation triage.
Appl Radiat Isot
; 131: 1-7, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29080427
ABSTRACT
The γ-H2AX assay was investigated as an alternative to the time-consuming dicentric chromosome assay (DCA). Radiation doses to 25 radiotherapy patients were estimated in parallel by DCA and the γ-H2AX assay. The γ-H2AX assay yielded doses in line with the calculated equivalent whole body doses in 92% of the patients, whereas the success rate of DCA was only 76%. The result shows that the γ-H2AX assay can be effectively used as a rapid and more precise alternative to DCA.
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Base de dados:
MEDLINE
Assunto principal:
Radiometria
/
Dosagem Radioterapêutica
/
Histonas
/
Aberrações Cromossômicas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article