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The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study.
Ward, Stephanie Alison; Storey, Elsdon; Woods, Robyn L; Hamilton, Garun S; Kawasaki, Ryo; Janke, Andrew L; Naughton, Matthew T; O'Donoghue, Fergal; Wolfe, Rory; Wong, Tien Y; Reid, Christopher M; Abhayaratna, Walter P; Stocks, Nigel; Trevaks, Ruth; Fitzgerald, Sharyn; Hodgson, Lauren A B; Robman, Liubov; Workman, Barbara; McNeil, John J.
Afiliação
  • Ward SA; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia; Monash Ageing Research Centre (MONARC), Monash University, The Kingston Centre, Warrigal Rd, Cheltenham 3192, Australia. Electronic address: Stephanie.Ward@monash.edu.
  • Storey E; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia; Department of Neuroscience (Medicine), Monash University, The Alfred Hospital, Commercial Rd, Melbourne 3004, Australia. Electronic address: elsdon.storey@monash.edu.
  • Woods RL; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: Robyn.Woods@monash.edu.
  • Hamilton GS; Department of Lung and Sleep Medicine, Monash Health, 246 Clayton Rd, Clayton, Vic 3168, Australia; School of Clinical Sciences, Monash University, 246 Clayton Rd, Clayton, Vic 3168, Australia. Electronic address: Garun.Hamilton@monash.edu.
  • Kawasaki R; Department of Vision Informatics (Topcon),Osaka University Graduate School of Medicine, E7 2-2 Yamada-oka, Suita-city, Osaka 565-1871, Japan. Electronic address: ryo.kawasaki@ophthal.med.osakau.ac.jp.
  • Janke AL; Centre for Advanced Imaging, University of Queensland, Building 57, Research Rd, The University of Queensland, St Lucia, QLD 4072, Australia. Electronic address: Andrew.janke@cai.uq.edu.au.
  • Naughton MT; The Department of Allergy, Immunology & Respiratory Medicine, Alfred Hospital, The Central Clinical School, Monash University, Commercial Rd, Melbourne, VIC 3004, Australia. Electronic address: M.Naughton@alfred.org.au.
  • O'Donoghue F; Institute for Breathing and Sleep, Austin Health, Heidelberg, VIC 3084, Australia; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Vic, Australia. Electronic address: Fergal.ODonoghue@austin.org.au.
  • Wolfe R; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: rory.wolfe@monash.edu.
  • Wong TY; Singapore Eye Research Institute, Singapore National Eye Center, 11 Third Hospital Avenue, 168751, Singapore; Duke-NUS Medical School, National University of Singapore, 8 College Rd, 169857, Singapore. Electronic address: Tien_yin_wong@nuhs.edu.sg.
  • Reid CM; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia; School of Public Health, Curtin University, Kent St, Bentley, Perth, WA 6102, Australia. Electronic address: chris.reid@monash.edu.
  • Abhayaratna WP; College of Medicine, Biology and Environment, Australian National University, Building 4, The Canberra Hospital, Hospital Rd, Garran ACT, Canberra 2605, Australia. Electronic address: Walter.P.Abhayaratna@act.gov.au.
  • Stocks N; Discipline of General Practice, Adelaide Medical School, University of Adelaide, Corner of North Terrace and George St, Adelaide, SA 5000, Australia. Electronic address: Nigel.stocks@adelaide.edu.au.
  • Trevaks R; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: ruth.trevaks@monash.edu.
  • Fitzgerald S; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: sharyn.fitzgerald@monash.edu.
  • Hodgson LAB; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Opthalmology), University of Melbourne, 32 Gisborne St, East Melbourne, VIC 3002, Australia. Electronic address: labh@unimelb.edu.au.
  • Robman L; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Department of Surgery (Opthalmology), University of Melbourne, 32 Gisborne St, East Melbourne, VIC 300
  • Workman B; Monash Ageing Research Centre (MONARC), Monash University, The Kingston Centre, Warrigal Rd, Cheltenham 3192, Australia. Electronic address: Barbara.Workman@monashhealth.org.
  • McNeil JJ; Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Rd, Melbourne 3004, Australia. Electronic address: john.mcneil@monash.edu.
Contemp Clin Trials ; 64: 101-111, 2018 01.
Article em En | MEDLINE | ID: mdl-29097299
PURPOSE: Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. DESIGN: SNORE-ASA is a sub-study of the ASPirin in Reducing Events in the Elderly (ASPREE) randomised, multi-centre, placebo-controlled trial evaluating the effect of daily 100mg aspirin on disability-free and dementia-free survival in the healthy older adult aged 70 and over. At baseline, 1400 ASPREE participants successfully underwent a home sleep study with a home sleep study screening device for SDB; and 296 underwent both 1.5 Tesla brain magnetic resonance imaging (MRI) and retinal vascular imaging (RVI). Cognitive testing, brain MRI and RVI is being repeated after 3years. PRIMARY OUTCOME MEASURES: Change in the modified mini-mental state examination score. Secondary outcome measures are changes in other cognitive tests, and changes in abnormal parameters on RVI and volume of white matter hyper-intensities on brain MRI. CONCLUSION: Identifying preventive therapies for delaying the onset of dementia is of paramount importance. The results of this study will help clarify the impact of the SDB on risk of cognitive decline and cerebral small vessel disease, and whether low-dose aspirin can ameliorate cognitive decline in the setting of SDB. SNORE-ASA TRIAL REGISTRATION: ACTRN12612000891820: The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov Number NCT01038583.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retina / Síndromes da Apneia do Sono / Anti-Inflamatórios não Esteroides / Aspirina / Cognição / Microvasos Idioma: En Ano de publicação: 2018 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retina / Síndromes da Apneia do Sono / Anti-Inflamatórios não Esteroides / Aspirina / Cognição / Microvasos Idioma: En Ano de publicação: 2018 Tipo de documento: Article