Link of impaired metal ion homeostasis to mitochondrial dysfunction in neurons.
Curr Opin Chem Biol
; 43: 8-14, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29100100
ABSTRACT
Manganese, iron, copper, and zinc are observed to play essential roles in mitochondria. The overload and depletion of metal ions in mitochondria under pathological conditions, however, could disturb mitochondrial compartments and functions leading to cell death. In this review, we mainly summarize how impaired metal ion homeostasis affects mitochondrial systems, such as membrane potentials, the tricarboxylic acid cycle, oxidative phosphorylation, and glutathione metabolism. In addition, based on current findings, we briefly describe a recent understanding of the relationship among metal ion dysregulation, mitochondrial dysfunction, and the pathogeneses of neurodegenerative diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Metais Pesados
/
Homeostase
/
Mitocôndrias
/
Neurônios
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article