Next-generation sequencing reveals novel resistance mechanisms and molecular heterogeneity in EGFR-mutant non-small cell lung cancer with acquired resistance to EGFR-TKIs.

Lee, Choong-Kun; Kim, Sora; Lee, Jae Seok; Lee, Jeong Eun; Kim, Sung-Moo; Yang, In Seok; Kim, Hye Ryun; Lee, Jeong Ho; Kim, Sangwoo; Cho, Byoung Chul

Lee, Choong-Kun; Kim, Sora; Lee, Jae Seok; Lee, Jeong Eun; Kim, Sung-Moo; Yang, In Seok; Kim, Hye Ryun; Lee, Jeong Ho; Kim, Sangwoo; Cho, Byoung Chul.

Afiliação

Lee CK; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
Kim S; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Lee JS; Department of Pathology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
Lee JE; Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Kim SM; JE-UK Laboratory of Molecular Cancer Therapeutics, Yonsei Cancer Institute, Yonsei University College of Medicine, Seoul, Korea.
Yang IS; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Kim HR; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
Lee JH; Graduate School of Medical Science and Engineering, KAIST, Daejeon, Korea.
Kim S; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea. Electronic address: SWKIM@yuhs.ac.
Cho BC; Division of Medical Oncology, Department of Internal Medicine, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea; JE-UK Laboratory of Molecular Cancer Therapeutics, Yonsei Cancer Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address: cbc1971@yuhs.

Lung Cancer ; 113: 106-114, 2017 11.

Article em En | MEDLINE | ID: mdl-29110836

Assuntos

Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Receptores ErbB/antagonistas & inibidores; Neoplasias Pulmonares/tratamento farmacológico; Mutação; Inibidores de Proteínas Quinases/uso terapêutico; Adulto; Idoso; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/patologia; Progressão da Doença; Resistencia a Medicamentos Antineoplásicos/genética; Receptores ErbB/efeitos dos fármacos; Feminino; Frequência do Gene; Heterogeneidade Genética; Sequenciamento de Nucleotídeos em Larga Escala/métodos; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Masculino; Pessoa de Meia-Idade; Análise de Sobrevida

Palavras-chave

Epidermal growth factor receptor; Next-generation sequencing; Non-small cell lung cancer; Resistance mechanism; Tyrosine kinase inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Receptores ErbB / Neoplasias Pulmonares / Mutação Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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