PIM activity in tumours: A key node of therapy resistance.

Rebello, Richard J; Huglo, Alisée V; Furic, Luc

Rebello, Richard J; Huglo, Alisée V; Furic, Luc.

Afiliação

Rebello RJ; Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; Cancer Program, Biomedicine Discovery Institute and Department of Anatomy & Developmental Biology, Monash University, VIC, 3800, Australia.
Huglo AV; Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia.
Furic L; Prostate Cancer Translational Research Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, 3000, Australia; Cancer Program, Biomedicine Discovery Institute and Department of Anatomy & Developmental Biology, Monash University, VIC, 3800, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, 3010, Australia. Electronic address: luc.furic@petermac.org.

Adv Biol Regul ; 67: 163-169, 2018 01.

Article em En | MEDLINE | ID: mdl-29111105

ABSTRACT

ABSTRACT

The PIM kinases are proto-oncogenes which have been shown to facilitate cell survival and proliferation to drive malignancy and resistance post-therapy. They are able to suppress cell death signals, sustain PI3K/AKT/mTORC1 pathway activity and regulate the MYC oncogenic program. Recent work has revealed PIM kinase essentiality for advanced tumour maintenance and described tumour sensitivity to small molecule inhibitors targeting PIM kinase in multiple malignancies.

Assuntos

Resistencia a Medicamentos Antineoplásicos; Neoplasias/enzimologia; Proteínas Proto-Oncogênicas c-pim-1/metabolismo; Transdução de Sinais; Animais; Humanos; Neoplasias/genética; Neoplasias/patologia; Neoplasias/terapia; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Proteínas Proto-Oncogênicas c-myc/genética; Proteínas Proto-Oncogênicas c-myc/metabolismo; Proteínas Proto-Oncogênicas c-pim-1/genética

Palavras-chave

AKT; Breast; Cancer; MYC; PIM; Prostate; mRNA translation; mTOR

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Resistencia a Medicamentos Antineoplásicos / Proteínas Proto-Oncogênicas c-pim-1 / Neoplasias Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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