Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG I&#945;, a new auto-antigen in Sjögren×³s syndrome patients, in salivary duct epithelial cells.

Fujimura, Takanori; Fujimoto, Takashi; Itaya-Hironaka, Asako; Miyaoka, Tomoko; Yoshimoto, Kiyomi; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Kondo, Saori; Takeda, Maiko; Tsujinaka, Hiroki; Azuma, Masayuki; Tanaka, Yasuhito; Takasawa, Shin

Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG Iα, a new auto-antigen in Sjögren×³s syndrome patients, in salivary duct epithelial cells.

Fujimura, Takanori; Fujimoto, Takashi; Itaya-Hironaka, Asako; Miyaoka, Tomoko; Yoshimoto, Kiyomi; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Kondo, Saori; Takeda, Maiko; Tsujinaka, Hiroki; Azuma, Masayuki; Tanaka, Yasuhito; Takasawa, Shin.

Afiliação

Fujimura T; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Fujimoto T; The Center for Rheumatic Diseases, Nara Medical University Hospital, Kashihara 634-8522, Nara, Japan.
Itaya-Hironaka A; The Center for Rheumatic Diseases, Nara Medical University Hospital, Kashihara 634-8522, Nara, Japan.
Miyaoka T; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Yoshimoto K; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Yamauchi A; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Sakuramoto-Tsuchida S; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Kondo S; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Takeda M; The Center for Rheumatic Diseases, Nara Medical University Hospital, Kashihara 634-8522, Nara, Japan.
Tsujinaka H; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Azuma M; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Tanaka Y; Department of Oral Medicine, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.
Takasawa S; The Center for Rheumatic Diseases, Nara Medical University Hospital, Kashihara 634-8522, Nara, Japan.

Biochem Biophys Rep ; 2: 69-74, 2015 Jul.

Article em En | MEDLINE | ID: mdl-29124146

Palavras-chave

IFN, interferon; IL, interleukin; Interleukin-6; JAK, Janus kinase; Janus kinase; MSG, minor salivary glands; Regenerating gene; SS, Sjögren×³s syndrome; STAT, signal transducer and activator of transcription; Signal transducer and activator of transcription; Sjögren×³s syndrome

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2015 Tipo de documento: Article