Evidence of size-dependent effect of silica micro- and nano-particles on basal and specialized monocyte functions.
Ther Deliv
; 8(12): 1035-1049, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29125067
ABSTRACT
AIM:
To analyze the effect of silica particles on monocyte/macrophage functions. MATERIALS &METHODS:
Silica micro- and nanoparticles were obtained by the Stöber method. Their effect on monocyte/macrophage proliferation, activation, membrane integrity and metabolic activity were determined.RESULTS:
Silica particles inhibit cell proliferation while 10 nm nanoparticles (NPs) did not affect it. Similarly, silica particles induced strong cell activation. However, 10 nm NPs do not alter IL-12 or nitrite levels. Furthermore, bigger NPs and microparticles increase cell membrane damage and reduce the number of living cells but smallest NPs (10 and 240 nm) did not.CONCLUSION:
Cell activation properties of silica particles could be useful tools for immune stimulation therapy, while 10 nm NPs would be suitable for molecule transportation.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dióxido de Silício
/
Nanopartículas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article