Complex analyses of inverted repeats in mitochondrial genomes revealed their importance and variability.
Bioinformatics
; 34(7): 1081-1085, 2018 04 01.
Article
em En
| MEDLINE
| ID: mdl-29126205
ABSTRACT
Motivation The NCBI database contains mitochondrial DNA (mtDNA) genomes from numerous species. We investigated the presence and locations of inverted repeat sequences (IRs) in these mtDNA sequences, which are known to be important for regulating nuclear genomes. Results:
IRs were identified in mtDNA in all species. IR lengths and frequencies correlate with evolutionary age and the greatest variability was detected in subgroups of plants and fungi and the lowest variability in mammals. IR presence is non-random and evolutionary favoured. The frequency of IRs generally decreased with IR length, but not for IRs 24 or 30 bp long, which are 1.5 times more abundant. IRs are enriched in sequences from the replication origin, followed by D-loop, stem-loop and miscellaneous sequences, pointing to the importance of IRs in regulatory regions of mitochondrial DNA. Availability and implementation Data were produced using Palindrome analyser, freely available on the web at http//bioinformatics.ibp.cz. Contact vaclav@ibp.cz. Supplementary information Supplementary data are available at Bioinformatics online.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Evolução Molecular
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Genômica
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Genoma Mitocondrial
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Sequências Repetidas Invertidas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article