Paroxysmal Nocturnal Hemoglobinuria Assessment by Flow Cytometric Analysis.
Clin Lab Med
; 37(4): 855-867, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-29128072
ABSTRACT
Paroxysmal nocturnal hemoglobinuria (PNH) is an uncommon but frequently debilitating disease that, if untreated, may lead to death in up to 35% of patients within 5 years. Assessment of PNH clone size by flow cytometric analysis has increased in importance with the availability of therapeutic treatments, which prevent the hemolysis of red blood cells and, hence, the myriad symptoms that accompany the disease. This article addresses flow cytometric methodologies and highlights areas of importance in implementing testing, not only for classic PNH but also for other related bone marrow failure disorders, such as aplastic anemia and low-grade myelodysplastic syndrome.
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Base de dados:
MEDLINE
Assunto principal:
Citometria de Fluxo
/
Hemoglobinúria Paroxística
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article