Copper-Catalyzed Enantioselective Synthesis of ß-Boron ß-Amino Esters.

ABSTRACT

In this report, the enantioselective, copper-catalyzed borylation of ß-amidoacrylates is disclosed. A broad variety of biologically important α-aminoboronates has been prepared with consistently high levels of enantiocontrol using an inexpensive copper catalyst and a commercially available chiral ligand. The method can be applied to the synthesis of novel boron-containing dipeptides and hemiboronates.