Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency.
Proc Natl Acad Sci U S A
; 114(48): 12743-12748, 2017 11 28.
Article
em En
| MEDLINE
| ID: mdl-29133412
ABSTRACT
Obesity typically is linked to caloric imbalance as a result of overnutrition. Here we propose a cell-autonomous mechanism for adiposity as a result of persistent cell surface glucose transporter type 4 (GLUT4) in adipocytes resulting from impaired function of ankyrin-B (AnkB) in coupling GLUT4 to clathrin-mediated endocytosis. Adipose tissue-specific AnkB-KO mice develop obesity and progressive pancreatic islet dysfunction with age or high-fat diet (HFD). AnkB-deficient adipocytes exhibit increased lipid accumulation associated with increased glucose uptake and impaired endocytosis of GLUT4. AnkB binds directly to GLUT4 and clathrin and promotes their association in adipocytes. AnkB variants that fail to restore normal lipid accumulation and GLUT4 localization in adipocytes are present in 1.3% of European Americans and 8.4% of African Americans, and are candidates to contribute to obesity susceptibility in humans.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Anquirinas
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Adipócitos
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Transportador de Glucose Tipo 4
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Adiposidade
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Glucose
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Obesidade
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article