Hunting for the mutant without the MAP(K).
Cell Res
; 27(12): 1403-1404, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-29134957
ABSTRACT
In a paper recently published in Cell Research, Yu et al. identify two MAPK-related kinases, MAPK11 and HIPK3, as positive regulators of levels of mutant huntingtin protein, a toxic species highly involved in Huntington's disease (HD) pathology. The identification and validation of these kinases as therapeutic targets for knockdown in multiple relevant experimental model systems reveal novel potential approaches for treatment of HD.
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1
Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article