MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.

Yang, Lawei; Lin, Ziying; Wang, Yahong; Gao, Shenglan; Li, Qinglan; Li, Chunyan; Xu, Wenya; Chen, Jie; Liu, Tie; Song, Zeqing; Liu, Gang

Yang, Lawei; Lin, Ziying; Wang, Yahong; Gao, Shenglan; Li, Qinglan; Li, Chunyan; Xu, Wenya; Chen, Jie; Liu, Tie; Song, Zeqing; Liu, Gang.

Afiliação

Yang L; Clinical Research Center, Guangdong Medical University, Zhanjiang, 524001, China.
Lin Z; Clinical Research Center, Guangdong Medical University, Zhanjiang, 524001, China.
Wang Y; Clinical Research Center, Guangdong Medical University, Zhanjiang, 524001, China.
Gao S; Clinical Research Center, Guangdong Medical University, Zhanjiang, 524001, China.
Li Q; Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Li C; Clinical Research Center, Guangdong Medical University, Zhanjiang, 524001, China.
Xu W; Clinical Research Center, Guangdong Medical University, Zhanjiang, 524001, China.
Chen J; Department of Cardiothoracic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Liu T; The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shanxi, 710061, China.
Song Z; Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, China.
Liu G; Clinical Research Center, Guangdong Medical University, Zhanjiang, 524001, China.

Mol Carcinog ; 57(3): 419-428, 2018 03.

Article em En | MEDLINE | ID: mdl-29144562

Assuntos

Antineoplásicos/farmacologia; Cisplatino/farmacologia; Resistencia a Medicamentos Antineoplásicos; Neoplasias Pulmonares/tratamento farmacológico; MicroRNAs/genética; Células-Tronco Neoplásicas/efeitos dos fármacos; Proteínas rab de Ligação ao GTP/genética; Células A549; Linhagem Celular Tumoral; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Células-Tronco Neoplásicas/metabolismo; Células-Tronco Neoplásicas/patologia

Palavras-chave

MiR-5100; cancer stem cells; chemoresistance; cisplatin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Cisplatino / Resistencia a Medicamentos Antineoplásicos / Proteínas rab de Ligação ao GTP / MicroRNAs / Neoplasias Pulmonares / Antineoplásicos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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