The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor.
Elife
; 62017 11 17.
Article
em En
| MEDLINE
| ID: mdl-29148973
ABSTRACT
Mature T cells bearing αß T cell receptors react with foreign antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were exposed to during their development in the thymus, a phenomenon known as positive selection. The structural basis for positive selection has long been debated. Here, using mice expressing one of two different T cell receptor ß chains and various MHC alleles, we show that positive selection-induced MHC bias of T cell receptors is affected both by the germline encoded elements of the T cell receptor α and ß chain and, surprisingly, dramatically affected by the non germ line encoded portions of CDR3 of the T cell receptor α chain. Thus, in addition to determining specificity for antigen, the non germline encoded elements of T cell receptors may help the proteins cope with the extremely polymorphic nature of major histocompatibility complex products within the species.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Alelos
/
Antígenos de Histocompatibilidade
/
Complexo Principal de Histocompatibilidade
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article