Dropped Head Syndrome and the Presence of Rimmed Vacuoles in a Muscle Biopsy in Scleroderma-polymyositis Overlap Syndrome Associated with Anti-Ku Antibody.
Intern Med
; 57(6): 887-891, 2018 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-29151520
ABSTRACT
A 66-year-old woman with a history of interstitial lung disease presented with a 3-month history of dropped head syndrome (DHS), followed by camptocormia and extremity weakness. A clinical examination revealed Raynaud phenomenon, arthralgia, distal skin sclerosis, and microbleeds in the nailfold capillaries. An anti-Ku antibody test was positive. A muscle biopsy revealed inflammatory myopathy with rimmed vacuoles (RVs). The diagnosis of scleroderma-polymyositis (SSc-PM) overlap syndrome was made. RVs on a muscle biopsy in a patient with inflammatory myositis involving axial muscles may be seen either in inclusion body myositis or SSc-PM overlap syndrome. The examination of the skin and autoantibody testing help determine the diagnosis and treatment strategy.
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Base de dados:
MEDLINE
Assunto principal:
Azatioprina
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Prednisolona
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Doenças Pulmonares Intersticiais
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Miosite de Corpos de Inclusão
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Debilidade Muscular
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article